Abstract
Paracetamol (acetaminophen) is a widely used over-the-counter analgesic, antipyretic and a mild anti inflammatory drug. In several developing countries some of pharmaceutical industries sale fake, counterfeit and substandard drugs which affect the health of people. The present study investigates the comparison for the quantitative determination of various brands of paracetamol tablet using UV-Visible spectrophotometric, potentiometric and trimetric methods. Four brands (Pacimol, Paracip, Parazest, and Crocin) of paracetamol tablets having 500 mg strength were purchased from various pharmacy shops within Pari chowk and Jagat market in Greater Noida, India. Weight variation test was performed before the assay of paracetamol samples. The result of tablets weight variation (Mean ± S.D) of Crocin, Parazest, Paracip and Pacimol brand was 0.66 ± 0.014, 0.64 ± 0.010, 0.58 ± 0.007 and 0.55 ± 0.009 respectively. All brands showed different mean weight which indicates the use of different excipients in the different brands. The ranges of the amount of paracetamol content (g/tab) for paracetamol samples analyzed using UV-Visible spectrophotometric, potentiometric and trimetric methods were from 0.49195-0.52010, 0.48300-0.52100 and 0.48106-0.50110 respectively. The results indicated that all four brands of paracetamol tablets have sufficient quantity and amount is approximately similar to the company’s recommended or claimed value. Similarly, the ranges of percentage content (assay) of the analyzed samples using UV-Visible spectrophotometric, potentiometric and trimetric methods were from 98.69-104.20%, 96.60-104.20%, and 96.21-100.22% respectively. The assay results indicated that variation among all brands and this may show that different manufacturer formulates the different brands are under the IP specification. However, all of the brands of the tablets under the study were complied with the IP specification and passed for weight variation test and assay conducted on it. Hence, the drug control authority of the government should be continuously monitored the safety, quality, and efficacy of paracetamol tablet through post marketing surveillance practices, and the proper internal quality control of the pharmaceutical companies need to take further necessary steps to ensure the continuity in the establishment of the product quantity and quality.
 Keywords: Assay, Brands, Comparative, Determination, Paracetamol, Tablets
Highlights
Analgesics, antipyretics and nonsteroidal anti inflammatory drugs (NSAIDs) are the most commonly prescribed medications worldwide[1,2,3]
The present study investigates the comparison for the quantitative determination of various brands of paracetamol tablet using UV-Visible spectrophotometric, potentiometric and trimetric methods
Four different brands of uncoated paracetamol tablets having label strength of 500 mg for the test samples are shown in table 1
Summary
Analgesics, antipyretics and nonsteroidal anti inflammatory drugs (NSAIDs) are the most commonly prescribed medications worldwide[1,2,3]. Dr Tamiru Tilki et al, Journal of Biomedical and Pharmaceutical Research been proposed that the analgesic mechanisms action of paracetamol which involves prostaglandins (PGs), has a controversial result of inhibiting the central cyclo-oxygenases (COX-1, COX-2, and COX-3)[10]. It is available in different dosage form: tablet, capsules, drops, elixirs, suspension, and suppositories. It gives the amount of one or more components present in the sample in numerical terms[18] The motto behind this quantitative estimation is to ensure that whether a particular drug contains the same amount of drugs as mentioned because if the dose given will be high it will cause over dosage side effects and if is less the patient will not get the required dose[19]. The present study investigates the comparison for the quantitative determination of four brands of paracetamol tablet using UV-Visible spectrophotometric, potentiometric and trimetric methods
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
