Abstract
Background: The objective of study was to compare Etomidate and Propofol as induction agents and their effect on Pain on injection, time to loss of consciousness and myoclonic movements.
 Methods: The study was carried out on 100 patients of ASA grade I and II between 18-58yrs of age of either sex enrolled for this prospective randomized double blind study, admitted in K D Medical College, Hospital & Research Center, Mathura (U.P) and scheduled for elective surgical procedures under general anaesthesia and endotracheal intubation.
 Results: The incidence of pain on injection in propofol group was more as compared to etomidate group (p value <0.05). In propofol group 25(50%) patients while in etomidate group only 2(4%) patients had pain on injection. Etomidate group had significantly more myoclonic movements than propofol group (p value <0.05). In etomidate group 18(36%) patients had myoclonic movements of various severity, while in propofol group no patient had myoclonic movements.
 Conclusion: Incidence of apnoea on induction was more in propofol group than etomidate group but comparison was not statistically significant.
 Keywords: Apnea, Propofol, Etomidate.
Highlights
Before the introduction of intravenous anaesthetic inducing agents, the induction of anaesthesia was unpleasant, time consuming and at times stormy
Incidence of apnoea on induction was more in propofol group than etomidate group but comparison was not statistically significant
Induction of anaesthesia is known to be associated with hemodynamic variations of mild to moderate degree depending upon many factors
Summary
Before the introduction of intravenous anaesthetic inducing agents, the induction of anaesthesia was unpleasant, time consuming and at times stormy. Induction agents are drugs that, when given intravenously in an appropriate dose, cause a rapid loss of consciousness This is often described as occurring within “one arm-brain circulation time” that is the time taken for the drug to travel from the site of injection (usually the arm) to the brain, where they have their effect. Propofol is a lipid soluble alkyl phenol derivative, which acts at gaba receptors and blocks neurotransmission It has a rapid onset of action and fast recovery. It may cause hypotension and respiratory depression.[4] Etomidate is another induction agent, which is considered to be better than propofol as it provides better haemodynamic stability of the patient during induction as proved in many studies.[5]. We designed a randomized double blind prospective study with hypothesis that etomidate will prove to be a better induction agent than propofol
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