A COMPARATIVE STUDY BETWEEN EFFICACY OF TOPICAL INSULIN AND NORMAL SALINE DRESSINGS IN DIABETIC FOOT ULCERS.

Abstract

Introduction: One of the most prevalent problems a surgeon encounters is chronic wounds, especially those that do not heal. The development of agents for wound healing is the subject of ongoing study. Insulin is one such substance that stimulates connective tissue. Objective: To evaluate the effectiveness of topical insulin dressings with traditional saline dressings in the healing of chronic diabetic foot ulcers (DFUs), in terms of the size of the ulcer, the amount of time spent in the hospital, and any side effects. In this prospective longitudinal study,the Materials and Methods: patient's willingness to receive topical insulin therapy was used to separate the study population (n=100) into study group (insulin group, n=50) and Control group (saline group, n=50). Using paired and unpaired Student's t-tests, the variables of ulcer surface area, granulation tissue formation and length of hospital staywere compared. A p-value of < 0.05 was deemed signicant. In t Results: he study group, the mean ulcer surface area was 40.4 cm2, compared to 37.6 cm2 in the control group (p-value = 0.012). After dressings, the mean area of granulation tissue formation in the study group was 39.63 cm2+2.6 , while it was 36.07 cm2+ 5.7 in the control group (p-value=0.001*). The control group's average hospital stay was 31.3 + 4.2 days whereas in the study group it was 27.8 ± 2.4 days (p-value=0.001*). Insulin is a chea Conclusion: p and superior alternative dressing agent for diabetic foot ulcer care