A comparative study between benign and malignant conditions of upper gastrointestinal tract of helicobacter pylori using upper gastrointestinal scopy in a tertiary care hospital, Kanchipuram, Tamil Nadu, India

Abstract

Background: Acid peptic disease comprises of a wide spectrum of diseases, which cause considerable morbidity. The objective of this study was to study the prevalence of Helicobacter pylori in patients with dyspepsia and symptomatic patients undergoing upper gastrointestinal endoscopy (UGIE) in Karpaga Vinayaga Medical College and Hospital, Kanchipuram, Tamilnadu, India and to study the association of Helicobacter pylori with acid peptic diseases and malignant conditions of upper Gastro intestinal tract.Methods: 389 cases of dyspepsia, studied clinically, were subjected to UGIE, during which 4 biopsies, two each from the antrum and the pathological areas were taken. One of the antral area and the other of the pathological finding were immediately subjected to Rapid urease test. Positive test for Helicobacter pylori was indicated by change in colour of the medium from yellow to pink or red. The other two biopsy specimens were sent for routine histopathology and special staining with Giemsa stain. The case was taken as Helicobacter pylori positive when the rapid urease test and/or histopathological examination was positive.Results: Out of 468 patients, with mean age of 41.8 years, 171 patients were diagnosed to have been infected with Helicobacter pylori (44.21%). Out of 49 patients with gastric and duodenal ulcers, 37 patients were infected with Helicobacter pylori (75.51%). In which 22 out of 25 patients (88%) with duodenal ulcers and 10 out of 14 patients (71.4%) with gastric ulcers were positive for H. pylori while only 8 out of 10 patients (80%) with gastric cancer were positive for H. pylori.Conclusions: In this study, we found that Helicobacter pylori were consistently associated with peptic ulcer disease and malignant conditions of upper GI tract, which is in broad agreement with the studies done earlier. Thus, we conclude that, Helicobacter pylori infection may have a major role in the etiopathogenesis of peptic ulcer disease and malignant conditions of upper GI tract appear to be no significant association between Helicobacter pylori infection and unexplained dyspepsia.