A comparative research of protective effects of TASCE and TACE on treatment of primary liver cancer

Abstract

Objective To investigate the clinical effects of transcatheter arterial chemoembolization(TACE) and transcatheter arterial segmental chemoembolization(TASCE) on treatment of primary liver cancer.Methods Eighty patients of liver cancer after hepatitis B were selected retrospectively.Forty patients were treated with TACE and 40 patients with TASCE.Their serum levels of ALT,AST,TBil,ALB at 1 day after the surgery,1 week after the surgery,4 week after the surgery were detected.Rates of tumor shrinkage were calculated by CT a month after the surgery.Results Serum levels of ALT in TACE group one day after surgery,one week since surgery,4 weeks since surgery were (515.25 ±107.34),(196.80 ± 64.33) and (65.52 ± 10.20) U/L,and were significantly higher than those in TASCE group [(117.51±21.47),(82.13±28.31)and (58.38±8.34)U/L,separately](t =22.98,P＜0.01; t =10.32,P＜ 0.01 ; t =3.43,P ＜ 0.01).Serum levels of AST in TACE group one day after surgery,one week since surgery,4 weeks since surgery were (454.58 ± 83.09),(68.72 ± 8.13) and (43.62 ± 6.43) U/L,and were significantly higher than those in TASCE group[(123.51 ± 19.32),(48.68 ± 6.57) and (39.54 ± 5.12) U/L,(sep tely)] (t =24.55,P ＜ 0.01; t =12.13,P ＜ 0.01; t =3.14,P ＜ 0.01).Serum levels of TBil in TACE group on the day after surgery,after a week since surgery,after 4 weeks since surgery were (51.97 ± 6.23),(35.74 ± 4.56) and (20.04 ± 3.81) μmol/L,and were significantly higher than those in TASCE group[(25.36 ± 3.11),(23.65 ± 3.21) and (16.75 ± 1.89) μmol/L,separately] (t =24.17,P ＜ 0.01; t =13.73,P ＜ 0.01; t =4.89,P ＜ 0.01).Serum levels of ALB in TACE group on the day after surgery,one week since surgery,4 weeks since surgery were (33.54 ± 3.56),(30.74±3.12) and (32.78±4.11) g/L,and were significantly lower than them in TASCE group[(37.67 ±5.34),(36.95±3.60) and (38.23±3.68)g/L,separately](t =-4.06,P＜0.01; t =-8.24,P＜0.01; t =-6.25,P＜0.01).In the type of tumor with morphology of dense iodine oil,rate of tumor shrinkage in TASCE group(86.36％) was significantly higher than TACE group(50.00％) (x2=5.96,P＜0.05).Conclusions In clinical treatment for primary liver cancer,clinical effects and hepatoprotection of TASCE group are hbtter than TACE group. Key words: Liver neoplasms; Hepatitis B; Transcatheter arterial segmental chemoembolization; Transcatheter arterial chemoembolization