A COMPARATIVE PROSPECTIVE STUDY TO ASSESS THE CLINICAL EFFICACY OF ITOPRIDE HYDROCHLORIDE (50MG) VS RABEPRAZOLE (40MG) IN PATIENTS WITH GERD.

Abstract

Background: The chronic condition known as gastroesophageal reux disease (GERD) causes symptoms and complications when stomach acid and contents increase into the oesophagus. Acid reux, breathing difculties, bad breath, tooth deterioration, chest pain and regurgitation are some of the symptoms. Barrett's oesophagus, esophageal stricture and esophagitis are all complications. Usually, cases that are refractory or when complications from reux disease are discovered necessitate surgery (fundoplication). For the treatment of GERD, a stepwise process is used. Controlling symptoms, treating esophagitis, and avoiding complications like recurrent esophagitis are the objectives. This was a prospective observational study in department of gastroenterology carri Methods: ed out for a period of six months. Patient data were extracted from their medical records. The present prospective comparative study was carried out at Department of Gastroenterology in tertiary care hospital in Hyderabad for a period of six months. The patients enrolled in this study 100, having 50 patients in each group. Our study reveals that most of the p Results: atients affected with GERD presented with complaints of heartburn, abdominal pain, chest pain, dysphagia, nausea. The recovery rate with rabeprazole in patients with GERD was found to be 68.57%. The recovery rate with itopride hydrochloride (ganaton) was found to be 74.28%. Conclusion: Ÿ The present study that is carried out showed that Itopride provided more effectiveness in treatment in patients with GERD. Ÿ In terms of efcacy, the Itopride is more effective in altering the symptoms of GERD therby reducing the score of FSSG scale than PPI (pantoprazole) alone. Ÿ In terms of side effects, the Itopride shows lesser side effects when compared to PPI in patients with GERD