Abstract
Esomeprazole is the S-isomer of Omeprazole and it is a proton pump inhibitor (PPI). Esomepra-zole is used in acid-related disorders and it is available as several brands in the market which makes it difficult for doctors to select the effective, safe and economic one for patients. Therefore we have decided to establish pharmaceutical equivalence among the different brands of esomeprazole available in Karachi, Pakistan. In our present study different brands of esomeprazole are evaluated for weight variation, hardness and dissolution. Disintegration Test shows results for NEX 01, ESS 02, EZI 03 and they disintegrate in 1.35, 1.15 and 2.15 minutes respectively. Dissolution test demonstrate the result as NEX 01, ESS 02, EZI 03 is 100.00% for NEX, 117.87% for ESS and 80.66%. The results showed that all parameters weight-variation, hardness, dissolution of different brands of esomeprazole are in accordance with the USP limits.
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