Abstract
1. The relative difference in rate of hydrolyses between acetylthiocholine (AcSCh) and propionylthiocholine (PrSCh) was smaller in sealice than in salmon brain homogenate, indicating a larger space for the acylgroup in sealice cholinesterase (ChE). Butyrylthiocholine (BuSCh) was poorly hydrolyzed in both species. 2. Substrate inhibition was observed at AcSCh concentrations higher than 5 mM in both salmon brain and sealice. 3. Km for AsSCh and PrSCh was found to be 0.22 mM and 0.71 mM in salmon brain, and 0.07 mM and 0.11 mM in sealice respectively (25°C). 4. The most selective ChE inhibitor towards sealice among those tested was paraoxon [k i ( sealice ChE) k i ( salmon brain ChE) = 59] . 5. The most potent inhibitor of cholinesterase among those tested was sarin on both salmon brain ( k i = 6.4 × 10 6) and sealice ( k i = 2.6 × 10 6).
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