Abstract
AbstractAutophagy is a catabolic pathway that promotes the degradation and recycling of cellular components. This process degrades proteins, lipids, and even whole organelles, which are engulfed in autophagosomes and delivered to the lysosome. Autophagy is a stress‐response that mediates the elimination of harmful cell components and recycles them to generate the nutrients and building blocks required to sustain cellular homeostasis. In addition, it plays an important role in cellular quality control, particularly in neurons, in which the total burden of altered proteins and damaged organelles cannot be reduced by redistribution to daughter cells through cell division. The role of autophagy in the retina and eye diseases is started to be investigated. I will review our main studies describing the role of autophagy in retinal development and cell differentiation, and discuss the implications of autophagy dysregulation both in physiological aging and in important diseases such as glaucoma and retinal dystrophies. Our findings reinforce the essential role of autophagy in maintaining proper retinal function and highlight novel therapeutic approaches for blindness and other diseases of the eye.
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