Abstract
The epithelial cystic linings and adjacent connective tissues of 61 cases of odontogenic cysts (radicular cysts[RC], dentigerous cysts[DC] and odontogenic keratocysts[OKC]) and unicystic ameloblastomas(UA) were described and compared histopathologically. The type of epithelium in relation to the presence of rete processes and the distribution of chronic inflammatory cells were analyzed statistically. Significant associations between the presence of rete processes in the non-keratinized epithelial linings and inflammation in the subjacent connective tissues of RC and DC were found in this study. There was also a statistically significant association between the presence of rete Processes and nonkeratinized epithelial linings in OKC. The results also showed that in inflamed OKC, the cystic lining epithelium exhibited hyperplasia indistinguishable from lining epithelium of RC and DC. This study further showed that ameloblastomatous-like epithelial cystic linings were present in inflammed odontogenic cysts. All except for one case of unicystic ameloblastomas in this study showed ameloblastomatous epithelial cystic linings. It is recommended that the lining epithelium of RC and DC be examined carefully in order to rule out OKC. Similarly, ameloblastomatous-like lining epithelium arising from chronic inflammation in RC and DC should be differentiated from true ameloblastomatous cystic lining. Such careful examinations are diagnostically important in view of the similarities of epithelial cystic linings of inflamed OKC with DC and RC aggressive behavior of OKC and UA.
Highlights
The epithelial linings of radicular cysts (RC), dentigerous cysts (DC) and odontogenic keratocysts(OKC) histologically may appear similar in areas of inflammation(l)
The odontogenic keratocyst linings in inflamed areas may present as a non-keratinized stratified squamous epithelium, which may appear similar to RC and DC. Such similarities in the appearance of odontogenic cyst linings (RC, DC and OKC) associated with inflamed areas would pose a diagnostic problem for odontogenic keratocyst as it maybe mistaken for dentigerous cysts
In view of the similar histopathological features and the presence of ameloblastomatous-like epithelial linings observed in different types of odontogenic cysts in areas of inflammation, it is the purpose of this paper to describe and compare the histopathological features of cyst linings of odontogenic cysts (RC, DC and OKC) and unicystic ameloblastomas
Summary
The epithelial linings of radicular cysts (RC), dentigerous cysts (DC) and odontogenic keratocysts(OKC) histologically may appear similar in areas of inflammation(l). Such similarities in the appearance of odontogenic cyst linings (RC, DC and OKC) associated with inflamed areas would pose a diagnostic problem for odontogenic keratocyst as it maybe mistaken for dentigerous cysts Such misdiagnoses should be avoided since the biologic activities of OKC differed from those of radicular or dentigerous cysts. In view of the similar histopathological features and the presence of ameloblastomatous-like epithelial linings observed in different types of odontogenic cysts in areas of inflammation, it is the purpose of this paper to describe and compare the histopathological features of cyst linings of odontogenic cysts (RC, DC and OKC) and unicystic ameloblastomas
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