Abstract
Publisher Summary This chapter presents a comparative histochemical mapping of the distribution of acetylcholinesterase and nicotinamide adenine dinucleotide–diaphorase (NAD-d) activities in the human brain. The chapter also discusses the reliability of histochemical mappings of Ache in the brain and the probable significance of the uneven distribution of Ache in various fiber tracts. A comparison of the distribution patterns of Ache in gray matter with those of other substances presumably involved in neuronal transmission is also presented in the chapter. The presentation of the data rests on microphotographs and a description of differences in terms of more or less staining. This shortcoming has been overcome for a few histochemical methods, e.g., for NAD-d that can be quantitated by extraction and spectrophotometric determination of the amount of formazan formed in the tissue by the histochemical reaction, using small discs punched from the tissue sections. No such method is available for the histochemical quantitation of Ache activity.
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