Abstract
BackgroundThe comparatively evaluate the three surgical treatment modalities namely cryosurgery, diode and CO2 laser surgery in terms of healing outcomes on the day of surgery, first and second week post operatively and recurrence at the end of 18 months was assessed.Material and MethodsThirty selected patients were divided randomly into three groups. Each group comprising of ten patients were subjected to one of the three modalities of treatment namely cryosurgery, diode laser or CO2 laser surgery for ablation of OL. Obtained data was analyzed using mainly using Chi-square and Anova tests.ResultsStudy showed statistical significant differences (p > 0.05) for evaluation parameters like pain, edema and scar. The parameters like infection, recurrence, bleeding showed no statistical significance. Pain was significantly higher in CO2 laser surgery group as compared with diode laser group. There was no recurrence observed at the end of the 6 months follow up period in all the three study groups.ConclusionsObservations from the study highlights that all three surgical modalities used in this study were effective for treatment of OL, and the overall summation of the results of the study showed that laser therapy (CO2 and Diode) seems to offer better clinically significant results than cryotherapy. Key words:Oral premalignant lesion, leukoplakia, cryosurgery, CO2 laser surgery, diode laser surgery.
Highlights
Oral cancer is one of the commonest of all cancers in India and only 10% are non-tobacco related [1]
Edema was recorded in 40% of the participants of cryosurgery group in the first week, whereas in CO2 and Diode laser surgery groups no edema was recorded
Scar formation was observed in 30% of the participants in the Cryosurgery group whereas there was no scar formation in both CO2 laser and Diode la ser groups, in the have reported complete regression of the lesions using cryotherapy on sixty patients with Oral leukoplakia (OL) [16]
Summary
Oral cancer is one of the commonest of all cancers in India and only 10% are non-tobacco related [1]. The risk of malignant transformation of OL is difficult to assess as suggested by Napier and Speight who reviewed clinical factors like age, sex, location and type of lesion responsible for the malignant transformation of OL and found that the result varied in different studies [5]. It is a premalignant lesion usually associated with tobacco usage and other factors being betel nut chewing and alcohol consumption [6]. Conclusion: Observations from the study highlights that all three surgical modalities used in this study were effective for treatment of OL, and the overall summation of the results of the study showed that laser therapy (CO2 and Diode) seems to offer better clinically significant results than cryotherapy
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