A Comparative Evaluation of Systemic Azithromycin and Ornidazole - Ofloxacin Combination as an Adjunct to Scaling and Root Planing In the Treatment of Chronic Generalised Periodontitis

Apurva Boid Sangeeta Muglikar

doi:10.4172/2161-1122.1000309

Abstract

Background: It is a well-established fact that various periodontal diseases are caused by bacteria, some of which are tissue invasive. It has been suggested that an antibiotic strength 500 times greater than the usual therapeutic dose may be needed to be effective against bacteria arranged in biofilm. However, so far, the literature shows that the ideal treatment is mechanical removal of local factors followed by systemic anti-infective therapy. Aims and Objective: To evaluate and compare the clinical effects of systemic Azithromycin (AZM) and Ornidazole-Ofloxacin combination as an adjunct to Scaling and Root Planning in the treatment of patients with chronic periodontitis. Materials and Method: This was a comparative randomized clinical Study in which 30 patients with chronic periodontitis participated. Patients were randomly divided into 3 groups: The group1 received Scaling and Root Planning plus Azithromycin, group 2received Scaling and Root Planning plus Ornidazole?Ofloxacin combination and the group 3 (control) which received Scaling and Root Planning only. Clinical indices including Probing Pocket Depth (PPD), Relative Attachment Level (RAL), Gingival Index (GI), and Plaque Index (PI) were measured at the baseline, 4 and 8weeks after treatment. Results: Comparison of the clinical parameters showed statistically significant improvement in all the three groups. SRP plus Azithromycin group showed additional benefit than SRP plus Ornidazole-Ofloxacin and SRP alone.

Highlights

Chronic periodontitis is an infectious disease with a bacterial etiology causing inflammation and progressive destruction of the tooth supporting tissues [1,2]
The conventional therapy for periodontal diseases consists of scaling and root planning or surgical treatment in order to gain a better access for root instrumentation [3,4]
The aim of the present study is to evaluate and compare the clinical effects of systemic Azithromycin (AZM) and Ornidazole-Ofloxacin

Summary

Introduction

Chronic periodontitis is an infectious disease with a bacterial etiology causing inflammation and progressive destruction of the tooth supporting tissues [1,2]. It has a considerable potency against gram negative organisms. Mascarenhas et al [14] have reported the beneficial effects of AZM in decreasing probing depth and increasing attachment levels compared to SRP alone in smokers with periodontitis. Angaji et al [16] showed that there was inadequate evidence for supplementary effect of adjunctive antibiotic therapy on chronic periodontitis in smokers. It is a well-established fact that various periodontal diseases are caused by bacteria, some of which are tissue invasive. The literature shows that the ideal treatment is mechanical removal of local factors followed by systemic anti-infective therapy

Methods

Results

Conclusion