A Comparative Evaluation of Postoperative Symptoms and Limitations in Function after Periradicular Surgery with and without use of Platelet Rich Fibrin as an Adjunct –A Randomized Clinical Trial

Abstract

Background and objectives: All surgical procedures produce some secondary effects such as pain, swelling, and some functional impairments like difficulty in chewing mouth opening, speaking, sleeping, etc. Controlling postoperative discomfort may improve the patient's quality of life and acceptance of the treatment. The goal of this randomized single-blind trial was to see if using platelet-rich fibrin during endodontic surgery had a positive impact on pain and other aspects of the patient's quality of life in the first week after surgery. Methods: Fifteen patients with periapical lesions were treated with endodontic surgical procedures (control group). In another 15 patients, platelet-rich fibrin was placed into the bone defect in the form of a clot, and a suture was applied in addition to the surgical procedure (test group). During the first week after surgery, all patients completed a questionnaire to assess their major symptoms and daily activities. The results of the two groups' questionnaires were statistically compared. Results: The test group reported less pain, symptoms (swelling and bad taste), and functional activities compared with the control group but the difference was not statistically significant. Conclusion: The adjunct of platelet-rich fibrin to the endodontic surgical procedure produced some beneficial effects on patients' quality of life during the early postoperative stage. There were insufficient data in the literature and more clinical trials with larger samples have to be carried out in the future to find out the outcome