A Comparative evaluation of platelet-rich fibrin with metronidazole and platelet-rich fibrin alone in the treatment of intrabony periodontal defects: A clinical and radiographical study

Abstract

Aim: The study comparatively evaluated the efficacy of platelet rich fibrin (PRF) with metronidazole and PRF alone in the treatment of intrabony periodontal defects both clinically and radiographically. Methods: A total no. of 20 subjects maintaining good oral hygiene with minimum two sites having vertical bony defects were selected using CBCT. All subjects were randomly assigned to anyone of the two groups (group A PRF+MTZ ; group B PRF only) using lottery system. All subject underwent open flap debridement and placement of either of the material mentioned above and a periodic follow-up at 6 and 9 months. Results: Improvement in clinical parameters (Plaque index, gingival index, probing depth, relative attachment level) as well as in radiographic parameters (defect depth and defect volume) as compared to baseline in both the groups was observed with group A exhibiting higher statistically significant values as compared to group B. Conclusion: The combination of PRF+MTZ were proven to be better than PRF alone. Further, long term clinical trials with larger samples of various drug concentrations and longer duration should be carried out to assess a complete periodontal regeneration rather than bone regeneration.