Abstract
Background and Objectives: C?reactive protein (CRP) is a type I acute phase reactant. A number of studies have reported elevated gingival crevicular fluid (GCF) CRP levels in periodontitis subjects, which decrease following periodontal therapy. Effect of diode laser as an adjuct to Scaling & Root planing is also well stablished. The aim of the present study was to evaluate the effect of periodontal treatment SRP with diode laser, on CRP levels in GCF in patients with chronic periodontitis.
 Materials and Methods: A total of 40 subjects with moderate periodontitis based on community periodontal index scores, were included in the study.
 Periodontal therapy was performed dividing each side of jaw as a group (Split mouth); one side SRP alone & another Diode laser with SRP. GCF was collected from each subject at
 Baseline (prior to treatment) and 1 month after periodontal therapy. The collected sample was subjected to biochemical analysis to detect CRP levels by using a commercially available highly sensitive kit.
 Results: The present study demonstrated that the mean CRP values at baseline were found to be 0.11043mg/l in side-I (side treated with SRP alone); 0.11042mg/l in side-II (side treated with SRP & laser) of the patient, which reduced to 0.4148 mg/L in side I and 0.3985mg/L in side II after treatment, which are highly significant according to statistical analysis but the changes between two sides were non- significant statistically.
 Interpretation and Conclusion: Within the limitations of this study, it can be concluded that periodontal therapy is able to reduce the GCF C reactive protein level significantly, but there was no statistically significant result in CRP level, between sides treated with SRP & SRP with laser.
 Key words: Chronic periodontitis, C?reactive protein, gingival crevicular fluid, Scaling and root planing, Diode laser
Highlights
Periodontitis is defined as “an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with increased probing depth formation, recession, or both.” 1 The pathogenic role of subgingival microbiota in initiation & progression of periodontitis is widely accepted
The present study demonstrated that the mean C‐reactive protein (CRP) values at baseline were found to be 0.11043mg/l in side-I; 0.11042mg/l in side-II of the patient, which reduced to 0.4148 mg/L in side I and 0.3985mg/L in side II after treatment, which are highly significant according to statistical analysis but the changes between two sides were non- significant statistically
Subjects were treated in 2 groups: Group I ‐ side treated with surgical periodontal therapy (SRP) alone & Group II - side treated with SRP and diode laser(980 nm)
Summary
Periodontitis is defined as “an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with increased probing depth formation, recession, or both.” 1 The pathogenic role of subgingival microbiota in initiation & progression of periodontitis is widely accepted Periodontal pathogens affect both local and systemic immune and systemic responses. Sometimes individual respond to microbial challenge cause high delivery of such inflammatory mediators as Prostanoid (PGE2), Interlukin-1(IL-1), Tumor necrosis factor (TNF) These cytokines cause destruction of both the periodontal connective tissue and alveolar bone.
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