Abstract
The development of surgical bioactive additives for regulation of the inflammation and enhance healing plays a critical role in clinical practice nowadays, inorder to speed up the process of healing this case report is presented to compare the additives with PRF as a common scaffold. PRF improves periapical healing when combined with other additions like Bone Graft (BG) and Mineral Trioxide Aggregate (MTA). The purpose of this comparative clinical study was to assess the periapical healing potential of plasma rich fibrin (PRF) as a scaffold in conjunction with MTA and bone graft. This investigation included two patients with a history of trauma and a significant periapical radiolucent lesion. The affected teeth were obturated with gutta percha utilising AH plus sealer after access opening and biomechanical preparation. Following that, periapical surgery was performed, and blood was collected from the patients to prepare PRF.A mixture of PRF and MTA was placed in the periapical defect of the first patient, whereas a mixture of PRF and BG was placed in the periapical defect of the second patient. A one-month, three-month, six-month, and one-year follow-up was performed to assess clinical and radiographic healing. Clinically, both patients were asymptomatic. The combination of PRF and BG resulted in superior radiographic healing.
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