A Comparative Clinical Study of Marham-e-raal and Povidone-Iodine 5% Ointment in Nonhealing Ulcers

Abstract

Introduction: Nonhealing ulcers are those that have not proceeded through timely and orderly reparation to produce anatomic and functional integrity. Povidone iodine is widely used ointment among physician and surgeons globally for wound dressings. In texts of Unani medicine literature, Marham-e-raal has been described as a potent ointment for gaining timely healing of wounds. The aim of this study is to compare the effects of povidone iodine and Marham-e-raal in nonhealing ulcers/chronic wounds. Methods: A randomized controlled study was carried out in the Department of Jarahat (Surgery) in National Institute of Unani Medicine, Bengaluru. A total of 45 subjects were included and randomized into Marham-e-raal and betadine dressing groups based on inclusion criteria. Dressing was done on daily basis and subjects were assessed on every 15 day from baseline to day 45 for primary outcomes (appearance of healthy granulation, epithelialization, and reduction in wound surface area) and secondary outcomes (decreases in tenderness score and depth of wound). Results: Nineteen out of 27 subjects in Marham-e-raal dressing group achieved complete healing as compared to one in povidone-iodine dressing group. There was significant reduction in wound surface area, median tenderness score and depth of wounds among subjects in Marham-e-raal dressing group at 0.05 level of significance. Conclusion: Marham-e-raal is an effective wound dressing and healing agent as compared to povidone-iodine ointment.