Abstract
Abstract not available.
Highlights
◾ From a rheological perspective, products exhibiting low yield stress and lower intrinsic viscosity will have better spreadability and require less effort to spread at the surface of the skin1,2 Yield stress is the minimum force required to make a structured fluid flow Viscosity describes a fluid’s resistance to flow
◾ Tazarotene 0.045% lotion was applied to one randomized half of the back and trifarotene 0.005% cream was applied to the opposite randomized half of the back (Figure 1)
◾ Two 10 cm wide application areas were marked with a gentian violet marker, one on each side of the back; this mark defined the lateral bounds over which the lotion or cream were spread
Summary
◾ This double-blind, split-body study enrolled male or female adults ≥18 years of age with normal back skin Participants, who provided written informed consent, were assessed for limited back hair which would prevent application of the study products. ◾ Tazarotene 0.045% lotion was applied to one randomized half of the back and trifarotene 0.005% cream was applied to the opposite randomized half of the back (Figure 1) The back was divided at the vertebral column into right and left Drugs were randomized for right or left application; the left back product was always pigmented blue and the right back product was always pigmented green. ◾ Two 10 cm wide application areas were marked with a gentian violet marker, one on each side of the back; this mark defined the lateral bounds over which the lotion or cream were spread. ◾ The lower extent of the study product application was marked with a gentian violet marker and measured in centimeters.
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