Abstract
Background: Point-of-care testing (POCT) plays an integral role in the management of acutely ill patients presenting to the emergency department (ED). Due to its rapid turnaround time, POCT has been shown to improve ED workflow, reduce unnecessary admissions and lessen the burden on ED staff. The aim of the study was to compare the accuracy, precision and linearity of the Nova Stat Profile Prime Plus® (Nova Biomedical, Waltham, MA, USA) to the Radiometer ABL800 FLEX® (Radiometer South Africa Pty Ltd, Gauteng) and the Abbott i-stat Chem8+® (Abbott, Princeton, NJ, USA) POCT analyzers.Methods: A convenience sample of 150 discarded whole blood specimens was obtained and analyzed. Paired test measurements were conducted for method comparison. Accuracy was measured by pairing individual results from the Nova Stat Profile Prime Plus® with either the Radiometer ABL800 FLEX® or the Abbot i-stat Chem8+® analyzers by calculating the differences.Results: The with-in run percentage coefficient of variation (%CV) was below 2.4% for pH, carboxyhemoglobin (COHb), deoxyhemoglobin (HHb), total hemoglobin (tHb), total bilirubin (tBil), sodium (Na), potassium (K), chloride (Cl), ionized calcium (iCa), urea, glucose and lactate, and was below 5.1% for all other analytes. The day-to-day %CV was below 1.6% for pH, COHb, HHb, tHb, tBil, Na, K, Cl, iCa, urea, glucose and lactate, and below 6.10% for all other analytes. The correlation coefficient (r) was 0.351 and ranged from 0.897 to 0.998 for all analytes. The mean bias was minimal for all analytes.Conclusion: There was a good correlation between the Nova Stat Profile Prime Plus® and the Radiometer ABL800 FLEX®/Abbott i-STAT Chem8+® POCT analyzers. The Stat Profile Prime Plus® exhibited good precision both within-run and day-to-day.
Highlights
Technological advances in point-of-care testing (POCT) have revolutionized the practice of emergency medicine over recent years [1,2]
The Nova Stat Profile Prime Plus® (Nova Biomedical, Waltham, MA, USA) is marketed as a compact maintenance-free Point-of-care testing (POCT) biochemical analyzer that is capable of measuring a comprehensive range of biochemical analytes including blood gas parameters, electrolytes, metabolites and co-oximetry from a single sample of blood in less than two minutes [9,10]
The objective was to evaluate the accuracy of this device by performing a method comparison with specific analytes measured by either the Radiometer ABL800 FLEX® (Radiometer South Africa Pty Ltd, Gauteng) or the Abbott i-STAT Chem8+®
Summary
Technological advances in point-of-care testing (POCT) have revolutionized the practice of emergency medicine over recent years [1,2]. By facilitating rapid clinical decision making and earlier targeted management of patients in the emergency department (ED), POCT has been shown to improve patient flow, reduce length of ED stay, decrease overall staff workload, improve patient satisfaction and reduce costs [35]. The objective was to evaluate the accuracy of this device by performing a method comparison with specific analytes measured by either the Radiometer ABL800 FLEX® (Radiometer South Africa Pty Ltd, Gauteng) or the Abbott i-STAT Chem8+®. The aim of the study was to compare the accuracy, precision and linearity of the Nova Stat Profile Prime Plus® (Nova Biomedical, Waltham, MA, USA) to the Radiometer ABL800 FLEX® (Radiometer South Africa Pty Ltd, Gauteng) and the Abbott i-stat Chem8+® (Abbott, Princeton, NJ, USA) POCT analyzers
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