Abstract
The objective of the present study was to investigate semen quality of infertile smokers and non-smokers including Benzo[a]Pyrene-7,8-diol-9,10 epoxide (BPDE)-DNA adduct formation and acrosome status of sperm cells. Semen quality parameters were analyzed according to 2010 World Health Organization criteria in 122 non-smokers and 125 cigarette smokers attending tertiary health care centre in Barak Valley of Assam, India followed by BPDE-DNA adduct formation and acrosome status test. A significant decline was found in sperm concentration, progressive motility, morphology in smokers (p
Highlights
Infertility, or the inability to conceive children after one year of unprotected intercourse, affects 10-15% of couples, who are trying to conceive (Rowe et al, 2000)
Due to the increasing incidence of decline in male fertility and high prevalence of tobacco use among the youths, an effort has been made to investigate the effect of cigarette smoking on semen quality of infertile men in Barak Valley of Assam in India mainly belonging to two groups – cigarette smokers and non-smokers
A comparative analysis of semen quality among 247 infertile men of reproductive age was carried out with an intention to elucidate the impact of tobacco smoking habit on semen quality
Summary
Infertility, or the inability to conceive children after one year of unprotected intercourse, affects 10-15% of couples, who are trying to conceive (Rowe et al, 2000). Benzopyrene[a]Pyrene (B[a]P), a byproduct of incomplete combustion of organic compounds such as gasolene, cigarette, wood, etc., is a polycyclic aromatic hydrocarbon which is metabolized in human body into various toxic forms (Revel et al, 2001). These metabolites bind with DNA forming a structure called Benzo[a]Pyrene-7,8-diol-9,10 epoxide (BPDE) which binds covalently with DNA forming BPDE-DNA adduct that has the capability to interfere with or alter DNA replication (Sipinen et al, 2010). Due to the increasing incidence of decline in male fertility and high prevalence of tobacco use among the youths, an effort has been made to investigate the effect of cigarette smoking on semen quality of infertile men in Barak Valley of Assam in India mainly belonging to two groups – cigarette smokers and non-smokers
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