Abstract
The BCL-2 family is conserved in evolution and shares a BCL-2 homology domain. It promotes and inhibits apoptosis. It is also known that apoptosis has a major role in effective cancer treatment. Therefore, it is of interest to document information related to the BCL-2 family of proteins for analysis by prediction tools. Hence, insights from a prediction based comparative functional analysis of 108 genes in this family are documented.
Highlights
One of the biggest challenges for evolutionary biologists in the post-genomic era has been a question of how phenotypic diversity arises
It is observed that some other domains are involved, which is not characteristic of BCL-2 family; they were not considered in the current study
BCL-2 family share homology clustered within four conserved regions BH1, BH2, BH3 and BCL-2 homology (BH)-4 control the ability of proteins to dimerize function as regulators of apoptosis
Summary
One of the biggest challenges for evolutionary biologists in the post-genomic era has been a question of how phenotypic diversity arises. Novel genes can rapidly integrate into existing and effectively drive the evolution of phenotypes [1]. It is the genes themselves and when, how and in what combination they are expressed in the cells is critical. Encoded BCL-2 founding member of the eponymous protein family was discovered more than 20 years ago at the chromosomal breakpoint t (14; 18) translocation in human follicular B-cell lymphomas [4,5,6,7,8]. The encoded BCL-2 gene localizes to intracellular membranes such as endoplasmic reticulum and mitochondria, and other family members translocated cytoplasm to mitochondria following a cell death stimulus. BCL-2 family of proteins are classified anti-apoptotic, pro-apoptotic and ISSN 0973-2063 (online) 0973-8894 (print)
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