A Comparative Analysis of Amytripiline, Flunnarazine and Topiramate in the treatment of Primary Headache

Abstract

Introduction 
 Primary headache disorder, characterized by recurrent headache is the most
 prevalent disease leading to widespread ill health and impaired quality of life.
 In Nepal headache is one of the most common cause of patient attending neurology
 clinic. Amitriptyline, Flunarizine and Topiramate are common drugs in the
 treatment of primary headache. We conducted this study to compare the efficacy of drugs namely Amitriptyline, Flunarizine and Topiramate in the treatment of primary headache
 Materials and Methods
 This is the retrospective data analysis of primary headache patient treated with
 amitriptyline, flunarizine and topiramate. On their first, second and
 third subsequent visits, Headache Impact Test 6 Scoring was done by a medical
 person. Patient were treated clinically. After third follow up data were
 analyzed using SPSS version 20.0. Categorical variables were compared by
 chi-square test, paired sample t-test, ANOVA test and Welch test.
 Results
 A total of 142 patient data was analyzed. The most common age group were
 between 20 to 39 years (56.34%) followed by 40 to 59 years (33.80%). Female were
 predominant in the group 124 (87.32%). All three medication Amitriptyline,
 Flunarizine and Topiramate were able to significantly lower Headache impact test 
 -17.23 ± 6.643, -14.06 ± 7.155, -15.82 ± 5.907 respectively (P- <0.001).
 Amitriptyline was found to be better than other two drugs in reducing Headache
 Impact Test.
 Conclusion 
 All three drugs namely Amitriptyline, Flunarizine and Topiramate, are significantly
 effective in the treatment of primary headache. Though tension type of headache is the most common type of headache, amitriptyline seems to be equally effective in treatment with other primary headaches.