Abstract
Trace analysis of liquid samples has wide applications in life science and environmental monitor. In this paper, a compact and low-cost photometer based on metal-waveguide-capillary (MWC) was developed for ultra-sensitive absorbance detection. The optical-path can be greatly enhanced and much longer than the physical length of MWC, because the light scattered by the rippled and smooth metal sidewall can be confined inside the capillary regardless of the incident-angle. For the photometer with a 7 cm long MWC, the detection limit is improved ~3000 fold compared with that of commercial spectrophotometer with 1 cm-cuvette, owing to the novel nonlinear optical-path enhancement as well as fast sample switching, and detecting glucose of a concentration as low as 5.12 nM was realized with conventional chromogenic reagent.
Highlights
A and much longer than the physical length of MWC, because the light scattered by the rippled and smooth metal sidewall can be confined inside the capillary regardless of the incident-angle
E Photometry is widely used for trace analysis of liquid samples, because abundant chromogenic reaT gents and semiconductor optoelectronic devices are available[1,2,3,4,5]
As for the multi-reflection cell, which was proposed for optical-path enhancement, the improvement on detection limit is only 2.5 fold[8,9]
Summary
For the photometer with a 7 cm long MWC, the detection limit is improved ~3000 fold compared with that of commercial spectrophotometer with 1 cm-cuvette, owing to the novel nonlinear optical-path enhancement as well as fast sample switching, and detecting glucose of a concentration as low as 5.12 nM was realized with conventional GOD-POD reagent. This compact and low-cost photometer would have wide applications in life science and environmental monitor for trace analysis
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