Abstract
The purification of radionuclides for medical applications presents unique challenges; most notably the needs for chemical purity, radionuclidic purity, and reliable production. To address these considerations, a new generator technology and instrument have been developed to permit the rapid chromatographic purification of clinically useful quantities of radionuclides for use in diagnostic or therapeutic nuclear medicine. The device comprises a separations module containing miniature chromatographic columns, a computer controller with driver software, and the fluid delivery components. This instrument is well suited for use in radionuclide generators as separations can typically be performed in 106. Chromatographic experiments targeting application in a 212Bi generator have demonstrated the usefulness of the Automated Radionuclide Separator as a low-pressure chromatography system.
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