Abstract
Gastric carcinoma (GC) is one of the most aggressive cancers and the second leading cause of cancer death in the world. According to the Lauren classification, this adenocarcinoma is divided into two subtypes, intestinal and diffuse, which differ in their clinical, epidemiological and molecular features. Several studies have attempted to delineate the molecular signature of gastric cancer to develop new and non-invasive screening tests that improve diagnosis and lead to new treatment strategies. However, a consensus signature has not yet been identified for each condition. Thus, this work aimed to analyze the gene expression profile of Brazilian intestinal-type GC tissues using microarrays and compare the results to those of non-tumor tissue samples. Moreover, we compared our intestinal-type gastric carcinoma profile with those obtained from populations worldwide to assess their similarity. The results identified a molecular signature for intestinal-type GC and revealed that 38 genes differentially expressed in Brazilian intestinal-type gastric carcinoma samples can successfully distinguish gastric tumors from non-tumor tissue in the global population. These differentially expressed genes participate in biological processes important to cell homeostasis. Furthermore, Kaplan-Meier analysis suggested that 7 of these genes could individually be able to predict overall survival in intestinal-type gastric cancer patients.
Highlights
Gastric cancer, one of the most aggressive cancers and the second leading cause of cancer-related death worldwide, is a multifactorial disease affected by lifestyle, aging, socioeconomic factors, dietary behavior and infection [1,2,3].The majority of gastric cancers are associated with infections agents, including Helicobacter pylori and Epstein-Barr virus [4,5]
We compared our intestinal-type gastric carcinoma profile with those obtained from populations worldwide to assess their similarity
The results identified a molecular signature for intestinal-type Gastric carcinoma (GC) and revealed that 38 genes differentially expressed in Brazilian intestinal-type gastric carcinoma samples can successfully distinguish gastric tumors from non-tumor tissue in the global population
Summary
The majority of gastric cancers are associated with infections agents, including Helicobacter pylori (present in 65% to 80% of cases) and Epstein-Barr virus (present in 6% to 10% of cases) [4,5]. The role of Helicobacter pylori in the emergence of gastric cancer has already been proposed, the role of Epstein-Barr virus is not yet clear because only a small group of patients harbor this infection [2, 6,7,8]. Late disease detection due to the nonspecific symptomatology in early stages remains a significant problem in gastric cancer that is associated with poor prognosis and a 5-year survival rate of approximately 20%. Many studies have attempted to elucidate gastric cancer biology to develop new noninvasive screening tests that improve diagnosis and facilitate the development of new treatment strategies
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
