Abstract
The myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia (AML) are seemingly unrelated diseases except for their origin in hematopoietic precursor cells in bone marrow. A principal feature of the myeloproliferative disorders, which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, is overproduction of blood cells. By contrast, a prominent feature of the myelodysplastic syndromes is a reduction in the number of one or more cells in the hematopoietic lineage. In AML, primitive myeloid cells in the bone marrow do not differentiate into mature granulocytes. These three groups of bone marrow disorders are distinct, yet they have overlapping features. Moreover, . . .
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