Abstract
GENERAL COMMENTARY article Front. Oncol., 28 May 2015Sec. Molecular and Cellular Oncology Volume 5 - 2015 | https://doi.org/10.3389/fonc.2015.00118
Highlights
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer by Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, et al Cell (2015) 160:700–14
Section of Pathology, Oncology and Experimental Biology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
The tumor microenvironment (TME) is rich in inflammatory cells and inflammatory mediators that strongly affect tumor growth and progression as well as metastatic spreading. It has been known for a while that tumor-infiltrating inflammatory cells such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAM) promote tumor growth, and several soluble factors, such as the CCL2 chemokine, the pro-inflammatory cytokines IL-1, IL-6, and TNFα, the pro-angiogenic factor VEGF are enriched in the TME (1)
Summary
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer by Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, et al Cell (2015) 160:700–14. PTX3 is produced locally, by macrophages and neutrophils and by endothelial and smooth muscle cells, in response to cytokines, pathogen-associated molecular patterns (PAMPs), intact microbes, oxidized-LDL, or HDL.
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