Abstract
A commentary on: "Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair".
Highlights
Unraveling the mechanisms that control the differentiation of oligodendrocyte precursor cells (OPCs) into mature myelinating oligodendrocytes (OLs) is central to improve the current treatments for demyelinating diseases such as multiple sclerosis (MS) (Franklin and ffrenchConstant, 2008)
Many studies have focused on the rodent OPC maturation, but less is known about human OPCs
These results suggested that activation of M3 muscarinic AChR (mAChR) inhibits OPC differentiation into OLs
Summary
Unraveling the mechanisms that control the differentiation of oligodendrocyte precursor cells (OPCs) into mature myelinating oligodendrocytes (OLs) is central to improve the current treatments for demyelinating diseases such as multiple sclerosis (MS) (Franklin and ffrenchConstant, 2008). Many studies have focused on the rodent OPC maturation, but less is known about human OPCs (hOPCs).
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