A COMBINATION OF HYPERTENSION AND A HIGH ATHEROGENIC INDEX OF PLASMA AS AN INDICATOR OF A CORONARY HEART DISEASE RISK

Abstract

Objective: Our study demonstrated the changes in the prevalence of coronary heart disease (CHD) depending on hypertension and atherogenic index of plasma Design and method: The atherogenic index of plasma (AIP) is a common logarithm of a ratio of triglycerides and HDL-cholesterol molar concentrations. According to M. Dobiasova (2006), at AIP < 0.10, cardiovascular risk is low; at the range of 0.10 to 0.24, the risk is medium, and if AIP is higher than 0.24, the risk is high. For the randomized sample of the ESSE-RF study, which included 1603 Krasnoyarsk Krai inhabitants, we used a standard questionnaire, anthropometry, office blood pressure measurement, and biochemical blood analyses to find a prevalence of known cardiovascular diseases and their risk factors. We registered hypertension if a person took antihypertensive medications or their measured blood pressure was at 140/90 mm Hg or higher. Coronary heart disease was diagnosed with a Rose angina questionnaire and 12-lead rest ECG encoded by the Minnesota system (the authors wish to thank the National Medical Research Center for Therapy and Preventive Medicine for assistance in laboratory tests and ECG encoding). Results: In 14.7% (95% CI = 13.8%-15.6%) of the study participants, we found CHD. Along with it, 73.5% of people had a low risk by AIP; in 10.4%, AIP indicated a medium risk, and 16.1% of the study participants had a high risk. People with normal blood pressure had no significant interrelation between the prevalence of CHD and AIP level (p = 0.669). Contrary, hypertensives with low risk by AIP had 23.2% (95% CI = 19.5%-27.0%) cases of CHD; at the medium risk, the prevalence of CHD was at 31.5% (95% CI = 21.8%-41.1%), and in the group of high risk, there were 17.5% (95% CI = 11.9%-23.1%) people with CHD. Chi-square was for trend at p = 0.036. Conclusions: The atherogenic index of plasma and coronary heart disease had no interrelation in normal blood pressure. In hypertension, however, the atherogenic index of plasma at a medium level may indicate a higher probability of coronary heart disease.