Abstract

Few studies have addressed the mechanism of chronic pain originating from musculoskeletal structure, in large part due to the lack of a reliable animal model of chronic muscle pain. The purpose of this study is to try to make an animal model of long-lasting muscle hyperalgesia, using a combination of eccentric muscle work and repeated cold stress (RCS). The mechanical withdrawal threshold in muscle was significantly decreased by RCS with or without eccentric muscle contraction (for at least 7 or 3 days after eccentric exercise or sham exercise, respectively). This result suggests that a combination of eccentric muscle work and RCS could prolong muscle hyperalgesia. However, the duration of the hyperalgesic state in this animal model was not considered long enough to be used in studies on the mechanism of chronic muscle pain. Further trials to elongate the period of hyperalgesia are needed.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.