Abstract
The aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb®, BCP) used in combination with hyaluronic acid (Hyadent®, HyA) gel for regeneration of osseous defects in a rat model. Bilateral femoral condylar bone defects (3 mm diameter and 3 mm depth) were created in 40 male Wistar rats. The defects were grafted as group I (BCP only), group II (BCP + HyA), group III (HyA only), and group IV (empty control). At four weeks and 10 weeks, the bone specimens were evaluated using histological and histomorphometrical analyses to identify the newly formed bone area (NF-BA (%)), as well as the remaining BCP particles (R-BCP (%)). Light microscopic examination indicated the absence of an inflammatory reaction within the bone defects after four weeks or 10 weeks of implantation. Significant new bone regeneration was present in the bone defects grafted with BCP or BCP + HyA biomaterials, as early as four weeks, compared to control groups. The addition of HyA to BCP did not significantly improve bone regeneration at four weeks or 10 weeks. Nevertheless, its role in bone healing and regeneration warrants further investigation.
Highlights
Periodontal disease caused by bacterial colonization of the subgingival biofilm evokes an inflammatory response, which leads to destruction of the periodontal tissues [1] such as the periodontal ligament and alveolar bone [2]
The present study aimed to evaluate the beneficial effect of adding hyaluronic acid (HyA) to biphasic calcium phosphate (BCP) for regeneration of femoral condylar defects in a rat model
Osseous defects grafted with BCP, in the present study, displayed significantly higher new bone formation as compared with the control defects, both at four weeks and at 10 weeks
Summary
Periodontal disease caused by bacterial colonization of the subgingival biofilm evokes an inflammatory response, which leads to destruction of the periodontal tissues [1] such as the periodontal ligament and alveolar bone [2]. The goal of contemporary periodontal therapy has always aimed at eliminating infection and restoring the periodontal bone defect [3]. Guided tissue regeneration and bone-grafting procedures have been used to regenerate bone within osseous defects, including that of the alveolar bone [4]. Bone-grafting materials are capable of providing a structural scaffold which stimulates and supports bone formation within osseous defects [4,5].
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