Abstract
A quantal technique for the potency assay in mice of adsorbed tetanus vaccines which uses paralysis as the criterion of a failure of protection is described. The results of the technique are compared with those provided by the more orthodox technique which uses death as the criterion of a failure of protection. The paralytic technique provides results comparable with those provided by the lethal technique and has the advantage that it may be used in a way that almost wholly eliminates animal suffering.
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