Abstract
Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
Highlights
As of this writing, Spain has the second highest number of confirmed severe acute respiratory coronavirus 2 (SARS-CoV-2) infections worldwide after the United States
In the multivariable logistic regression model, we found that male sex, older age, an oxygen saturation
To the best of our knowledge, this is the first report of a large cohort of patients hospitalized with COVID-19 in Europe
Summary
Spain has the second highest number of confirmed severe acute respiratory coronavirus 2 (SARS-CoV-2) infections worldwide after the United States. The healthcare systems of these regions are under massive stress, and the cumulative COVID-19 mortality per 100,000 inhabitants since the start of the pandemic has been high: 132 deaths in Lombardy, 140 in New York City and 190 in Madrid (as of 25 April) [4,5,6]. Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. Most patients admitted to the ICU were men, and the median age was 64 years. Male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes
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