Abstract
Abstract Rat blood cells (erythrocytes, platelets, lymphocytes and neutrophils) were washed and then suspended in Tyrode's solution containing 6% bovine albumin. When this mixture was passed through an isolated organ perfusion apparatus, but with no organ present, a clotting activity was generated that shortened the partial thrombo-plastin time of normal rat plasma. Further, assays of factors VI, VII, VIII, XI and XII suggested generation of these coagulation factors despite the absence of a liver or other organ. This artifact was abolished by carefully freeing the erythrocytes of the other blood cells. The artifact was directly traced to platelets, although the leukocytes may have made some contribution.
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