A clinicopathological study of morbidity and mortality of patients following radical cystectomy

Abstract

Background: Assessing the prognostic significance of specific clinicopathological features plays an important role in surgical management after radical cystectomy. Aim& Objective of the study: The current study is done to analyse the perioperative, early and late complications of tumors and also find out the mortality rate during radical cystectomy Methodology: This is a retrospective observational study conducted at NIZAMS INSTITUTE OF MEDICAL SCIENCES in Department of urology from September 2017 to September 2019. Results: In the present study, mean age of presentation is 58 yrs and range is 20 to 80 yrs. Among in total study population (60), 83.33% were male patients and 16.66% were female patients. Male: Female ratio is 5:1. All the smokers noted in the study were males. Thirteen members are smokers and all of them are males. The most common age group of presentation is 60-69 years (35%). Followed by 50-59 years (25%) followed by 40-49 years (20%). The most common presentation was painless hematuria seen in 61.66%. Followed by both hematuria and dysuria in 30% followed by only dysuria in 8.33%. Urine leak is the most common early complication seen in 10%. Ureteric stricture (5%), Pelvic recurrence 5 (8.33%) and distant recurrence 4 (6.66%) are the late complications. Out of 60 cases, 54 cases (90%) had high grade tumors while 6 cases (10%) had low grade tumors. Pelvic lymphnode involvement was seen in 18 patients (30%). In remaining 42 patients pelvic lymph node involvement was not seen (70%). Patients with lymph node positivity showed a 52% rate of survival while patients with negative lymph node status showed 80% survival. No deaths were recorded during the perioperative period. Conclusion: Our results revealed that several clinicopathological characteristics can predict CSS risk after radical cystectomy. Prospective studies are needed to further confirm the predictive value of these variables for the prognosis of bladder cancer patients after radical cystectomy.