Abstract
Aim: To study the clinicopathological spectrum of malignant tumors of the uterine corpus in a tertiary care center and classify it according to the latest WHO classification.
 Methods: A 2 year study was conducted on 22 diagnosed cases of malignant tumors of uterine corpus. Retrospectively clinical and histopathological details were collected and analyzed.
 Results: In our study majority (40.90%, 9 of 22) cases belong to the age group of 51-60 years. Abnormal uterine bleeding was the most common clinical presentation. A large share (81.81%) of the tumours was of epithelial origin, followed by mixed and mesenchymal tumors. Nearly 94% of the epithelial tumours were Endometrioid Adenocarcinomas. Majority of the cases were at pT1a stage (42.1%) at the time of diagnosis, followed by pT1b stage (31.57%). Very few cases (21%) presented with nodal metastasis. All the cases with nodal metastasis showed Lymphovascular invasion in the tumor proper and were usually high grade tumors.
 Conclusion: The prognosis of the patients with malignant tumors of uterine corpus depends on stage, grade, myometrial invasion, tumor size, lymphovascular invasion etc. Clinical findings in these tumors are not specific, so Histopathological examination plays a vital role in diagnosing and assessing the prognosis of these tumors. Classifying these tumors according to the recently proposed molecular classification will aid in patient specific targeted therapy.
Highlights
Cancer of the uterine corpus is a major gynecological malignancy that is responsible for mortality in women of reproductive and postmenopausal age
The aim of this paper is to study the clinicopathological spectrum such as demographic variables, presenting complaints, gross appearance, microscopic findings etc. of malignant tumors of the uterine corpus in a tertiary care center
Two cases of endometrial carcinoma were diagnosed with endometrial curetting specimen; pathological staging was not performed in these two cases
Summary
Cancer of the uterine corpus is a major gynecological malignancy that is responsible for mortality in women of reproductive and postmenopausal age. It is the 6th most common cancer among women worldwide and 2nd most common cancer of the female genital tract [1]. Almost 90% of the cancers in the uterine corpus occur in the endometrium [2]. Long-term unopposed estrogen therapy or hormone treatment without progesterone causes frequent mutations in DNA replication and increases the risk of uterine cancers [3]. Changing trends in lifestyle and reproductive profile of women is a risk factor responsible for rise in the incidence of uterine cancer in India. All the other causative factors amount to almost 5% of uterine cancer [2]
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