A clinicopathological analysis of non-infectious granulomatous dermatoses

Abstract

Non-infectious granulomatous dermatoses involves a broad group of distinct reactive inflammatory conditions. They have overlapping morphological and clinical features and hence pose a diagnostic challenge to differentiate from other granulomatous dermatoses and affect the management of the patient. To study the histopathological patterns of non-infectious granulomatous dermatoses and to correlate with clinical features. It is a retrospective study for a period of 5 years at a tertiary care centre in central Karnataka.In the present study, out of 7273 skin biopsies there were 34 cases of non-infectious granulomatous dermatoses. Out of these 34 cases, granuloma annulare (50%) was the most common non-infectious granulomatous lesion followed by annular elastolytic giant cell granuloma (14%), foreign body granuloma (9%), tattoo granuloma (9%) perforating folliculitis (9%), xanthoma(6%) and xanthelasma (3%). Non-infectious granulomatous disorders of skin encompass a large group of disorders with overlapping features. Thus adequate clinical data and subtle histological findings are important for specific diagnosis which provides better patient management.