“A CLINICO-MORPHOLOGICAL STUDY OF SMALL LUNG BIOPSIES”

Abstract

Background: Small lung biopsies have become the primary method of diagnosis when a radiological abnormality is detected and tissue diagnosis is required. Lung carcinoma, being the most common cause of cancer mortality in India and worldwide, kills more people than breast and prostate cancers combined. Histopathological characterization of lung cancers by small lung biopsy techniques have helped in guiding therapeutic modalities and genomic classication of lung carcinoma. The highest diagnostic success will be achieved by the multidisciplinary work up between the pathologist, radiologist and clinician altogether. Objectives Of The Study: 1. To evaluate the utility of cytology and histopathology in diagnosing small lung biopsies. 2. To study and tabulate the clinicopathological prole of patients diagnosed by small lung biopsies. Materials And Methods The present prospective study was conducted in the central diagnostic laboratory of a tertiary care teaching hospital in Dakshina Kannada District. This was a 2-year study of 87 small lung biopsy specimens. The histopathological, cytological, radiological and clinical records of the patients were studied for small lung biopsies between September 2020 to august 2022. All the examination ndings and relevant results were noted. A total of 87 small lung biopsy specimens (67 ma Results: les and 20 females) were studied for a period of 2-years. The average age of the study population was 62.8+/- 9.85 years. Majority of the patients presented with loss of weight. The benign(non-neoplastic) lesions constituted 13(14.9%) of the total number of biopsies (87) while the malignant cases were 74(85.1%). Maximum number of cases 39(44.8%) were reported in the age group of 61-70 years with male preponderance. In all the age groups, malignant lesions were more common in which Adenocarcinoma (Mucinous and Non-mucinous) is the most predominant with 23 cases (31.08%) followed by Squamous Cell Carcinoma of lung with 22 cases (29.7%) and metastasis in lung with 10 cases (13.5%). To conclude, t Conclusion: he present study explored the usefulness of cytology, histopathology and immunohistochemistry in the diagnosis of various lung lesions from materials obtained as a part of small lung biopsies.