A clinical trial on preventive effects of licorice on propranolol-related dizziness, a side-effect in patients with migraine headache

Abstract

Background/Aims: This trial aimed to evaluate Licorice preventive effects on dizziness, a side effect of propranolol in patients with migraine headaches (systolic blood pressure < 120 mmHg). Methods: Forty patients (systolic blood pressure ˂120 mmHg) who received propranolol (prophylactic medicine) were subjected and divided into Licorice and placebo groups. Dizziness frequency and severity, systolic and diastolic blood pressure, and orthostatic hypotension were assessed after three months. Headache frequency and severity in groups were examined via the Migraine Disability Assessment Test (MIDAS) to evaluate the licorice impact on migraine and response to treatment. Results: Dizziness frequency and incidence and orthostatic hypotension incidence were significantly reduced in the Licorice group more than those of placebo, while dizziness severity was almost similar. Finally, systolic and diastolic blood pressure values increased in the Licorice group and decreased in the placebo. MIDAS and headache severity in both groups were the same. However, headache frequency in the Licorice group was lower than the placebo. Conclusion: Licorice maybe effective for the prevention of propranolol-induced dizziness and hypotension in patients with migraine headaches (systolic blood pressure < 120 mmHg). Furthermore, licorice may increase patient tolerance in receiving propranolol and ameliorate migraine attack frequency. Keywords: Migraine; Dizziness; Orthostatic hypotension; Licorice; Propranolol.