Abstract
Summary This study was performed on 84 Thai soldiers infected with either Plasmodium falciparum or P. vivax at Camp Chakrapongs Army Hospital, PrachinburiProvin.ee, Thailand. Following treatment with halofantrine (three 500 mg doses at 6 h intervals), complete parasite clearance occurred within 53.6 h in allpatients. Recrudescence of parasitaemia was not seen during 28 days follow-up. Haematological and biochemical values were not significantly altered by treatment. Nevertheless, a slight increase in white blood cell counts was observed post-treatment. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) levels were slightly increased in some patients, but alkaline phosphatase was not affected. The enzymatic changes returned to normal by day 7. This study suggested that halofantrine hydrochloride at a dose of 500 mg three times daily at 6 h intervals was highly effective and free from significant clinical and biochemical side-effects when used for the treatment of mild-to-moderate P. falciparum and P. vivax malaria in an area where chloroquine resistance is prevalent.
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