Abstract
Lower urinary tract infection (UTI) is very common diseases. Recurrent UTI remain challenging to treat because the main treatment option is long-term antibiotic and this poses a risk for the emergence of bacterial resistance. Some options to avoid this risk are available, including the use of cranberry and elderberry products (herbal products extract). However, this can lead to the advent of bacterial resistance. The cross sectional study was designed to evaluated the efficacy of above products. The study was conducted from 23 October 2019 to 28 October 2019 in Arif Memorial Teaching Hospital, Lahore, Pakistan. The subjects were outpatients aged 20 to 65 years. UTI symptoms were recorded in the daily diary before, during and after treatment and assessed by the Jackson score. Following approval by the Ethics Committee of Rashid Latif Pharmacy College, the questionnaire (ROUTE2-002) was compiled and information of UTI patients using cranberry and elderberry extracts (Berdi® Sachet) was collected. Compliance and tolerability were considerable obstacles in this study. A total of 67 patients were screened for participation; 12 were unwilling to participate and 55 were enrolled for clinical trial and all patients had urinary tract irritation. In this study 55 (100%) UTI patients were cured with cranberry and elderberry extracts (Berdi® Sachet). Further investigation is needed to confirm this effect and to evaluate the health benefits of cranberries and elderberry.
Highlights
Low urinary tract infections (UTI) are very common and it is estimated that at least 60% of women suffering at some stages in their lives [13]
This study focus on cranberry and elderberry extract in sachet form (Berdi® Sachet)
The most common organisms isolated from the index and recurring UTI were E. coli
Summary
Low urinary tract infections (UTI) are very common and it is estimated that at least 60% of women suffering at some stages in their lives [13]. Urinary tract infections in adult women are about 50 times higher than in men, as women have a shorter urethra and bacteria can go up into the bladder. Colonization of the peri-urethral tissues is the first step of infection followed by bacterial passage through the urethra. The second step is the proliferation of bacteria on the urethra and bladder wall [5,6]. Urinary tract infections are caused by Gramnegative bacteria. Risk factors for women with urinary tract infections include sexual intercourse, contraceptives, antibiotic resistance, menopause, genetics and bacterial virulence [2]
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