Abstract
SUMMARY The effects of a mixture of 1 part levallorphan and 10 parts levorphanol taken by mouth were studied in subjects needing symptomatic control of intractable pain. Response varied according to previous treatment with potent analgesics. The effects were similar to those of the same dose of levorphanol alone in patients not already receiving drugs of addiction. The incidence of side effects was high after long-term opiate therapy. These appeared to be levallorphan-induced abstinence symptoms and were also troublesome when the mixture was given for long periods to patients who had not previously received addicting drugs. Side effects became evident after two or three weeks and render this drug combination unsuitable for clinical use.
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