Abstract
SummaryA double-blind placebo controlled trial to evaluate the efficacy of 'Hydergine' in patients suffering from mild to moderate cerebrovascular insufficiency due to cerebral arteriosclerosis is described. A certain number of cases of senile dementia were inevitably included due to the difficulty in differentiating the two conditions. Of the original 58 patients, 26 in each group completed the 12-week study period. The 6 patients failing to complete did so for reasons not related to the drug under investigation. Assessment of 22 factors divided into 4 main symptom complexes was made at 4-week intervals for 12 weeks. Statistical significance in favour of'Hydergine'' was achieved in 3 of the 4 symptom complexes: Physical manifestations, p < 0.01; Motor activity p < 0.01; and Attitude and moodp < 0.05, while in the Daily living activities complex p < 0.1.The physician's overall assessment of the patients' progress showed that the improvement of the 'Hydergine' patient group was greater than the placebo gro...
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