A Clinical Study on the Treatment of Peripheral Nerve Injury Growth Factor of Mecobalamin Combined with Nerve

Chengkua Huang,Wen Wei,Guosheng Su,Yong Zhao,Wenzhong Lu,Shuliang Hua,Yinwen Mai,Jili Lu

doi:10.4236/wjns.2016.62009

Abstract

Objective: This research aims to explore the clinical curative effect for the treatment peripheral nerve injury growth factor of Mecobalamin combined with nerve. Methods: 150 cases of patients with peripheral nerve injury treated in the hospital in July were selected from 2011 to 2013. Those patients were randomly divided into three groups according to the types of injured nerve and the undergoing treatment order. 50 cases are for each group. Patients in group A were injected with 0.5 mg Mecobalamin by intravenous injection. It lasted for once a day, for 10 days. Later, 0.5 mg Mecobalamin was changed to be taken orally, three times a day, a course of treatment. And a course is 3 to 6 weeks. 50 patients in group B were injected with nerve growth factor for 30 micrograms by intramuscular injection, once a day, a course of treatment. And a course is 3 to 6 weeks. While in group C, 50 patients were treated with Mecobalamin (0.5 mg, intravenous injection, once a day) combined with nerve growth factor (30 mg, intramuscular injection, once a day). A course lasted 3 to 6 weeks. The purpose is to observe the therapeutic effect of two different drugs on patients with peripheral nerve injury. Results: The curative effect of Mecobalamin combined with nerve growth factors for the treatment of peripheral nerve injury in group C is more significant than the single drug treatment in group A and group B. Peripheral nerve injury after sensorimotor function rating evaluation of curative effect made by The British Medical Research Institute of Neurotrauma Society was applied in this research. The comparison of the results of 3 groups after treatment is showed as follows. As to the sensory recovery above level II, the curative effect in C group is generally better than in group A and group B, the approximate chi square test H = 13.6573, P = 0.0011. About motion recovery situation, there is a statistical significance in group A and group C which recovered V level X2 = 3.8431, P = 0.0499, while there is no obvious difference in group B (P > 0.05). Conclusion: Some certain curative effect is presented of Mecobalamin combined with nerve growth factor in the treatment of peripheral nerve injury, which has an important clinical significance. Therefore, it is worth taking into application.

Highlights

Peripheral nerve injury is the injury of the peripheral nerve trunk or its branches directly or indirectly affected by the external forces
In order to find a way to treat the patients with peripheral nerve injury to achieve the best therapeutic effect, great efforts have been made in our hospital using comprehensive treatment measures in the clinical treatment of peripheral nerve injury
After observing the patients in the three groups undergoing six months treatment, it is found that the curative effect of Mecobalamin combined with nerve growth factors for the treatment of peripheral nerve injury in group C is more significant than the single drug treatment in group A and group B

Summary

Introduction

Peripheral nerve injury is the injury of the peripheral nerve trunk or its branches directly or indirectly affected by the external forces. Peripheral nerve functional recovery after treatment still cannot achieve the ideal effect, especially patients with complete nerve injury. How to better promote the recovery of neural function, and improve the patient’s life and work ability, so as to improve the quality of life are the need to solve the problem of clinician [1]-[3]. Peripheral nerve injury has always been a headache for clinical medical workers. In order to find a way to treat the patients with peripheral nerve injury to achieve the best therapeutic effect, great efforts have been made in our hospital using comprehensive treatment measures in the clinical treatment of peripheral nerve injury. Satisfactory results have been achieved, which can be shown as follows

Methods

Results

Discussion

Conclusion