Abstract
Objective To explore the clinical effect of auxiliary comprehensive management combined with growth patch in the treatment of childhood idiopathic short stature (ISS). Methods From September 2017 to December 2019, 120 children with ISS who met the selection criteria were collected. Random number table method divided them into 2 groups: one group was given auxiliary comprehensive management and recorded as the routine group (n = 60), and the other group was given auxiliary comprehensive management and combined growth patch treatment and recorded as the combination group (n = 60). The course of treatment was 12 months. The effects of the two methods on children's height, bone age, body weight, and insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels were compared. Results There was no statistical difference between the two groups in baseline height, genetic height, baseline bone age, baseline body weight, and body weight before and after treatment (P > 0.05). After treatment, the heights of the two groups were higher than before for the same group, the height growth values and predicted adult height of the combination group were higher than those of the routine group, and the predicted adult height of the combination group was higher than the genetic height of the same group (P < 0.001). There was no statistical difference in IGF-1 and IGFBP-3 levels before treatment between the two groups (P > 0.05). The levels of IGF-1 and IGFBP-3 after treatment in the two groups were higher than those in the same group before treatment, and the combination group was higher than that in the routine group (P < 0.05). Conclusion On the basis of auxiliary comprehensive management, combined with growth patch for the treatment of children with ISS, it can effectively increase the height of the children, improve the levels of serum IGF-1 and IGFBP-3, and have significant clinical effects, which is beneficial to the healthy growth of the children.
Highlights
Short stature in children refers to patients whose height is significantly shorter than the average height of the normal population by 2 standard deviations (−2SD) or lower than the third percentile (−1.88sd) among individuals of the same race, gender, and age under normal living standards, and the bone maturity is evaluated according to bone age and less than 2 years behind the actual age [1, 2]
Short stature belongs to the name of modern medicine, and according to its clinical manifestations, it can be classified into the category of “five delays” in Traditional Chinese Medicine. e main responsibility is the deficiency of the spleen and kidney, and it is related to the liver. e kidney is the congenital foundation, which controls the growth of bone marrow; the spleen is the foundation of acquired nature, which controls the metaplasia of qi and blood. e growth and development of the human body depend on the nourishment of the kidney essence and the transport and transformation functions of the spleen
Exclusion Criteria. 1 ose with Growth hormone (GH) deficiency, hypothyroidism and other endocrine diseases; 2 those with pituitary diseases, genetic metabolic diseases, skeletal development disorders, malnutrition, eating disorders, precocious puberty, and various chronic systemic diseases; 3 those with abnormal intellectual development or severe mental or emotional disorders; 4 those who were allergic to the drugs used in this study or had skin allergies; 5 those who had recently taken other drugs that affect serum insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels; 6 those who were unwilling to cooperate with this study
Summary
Short stature in children refers to patients whose height is significantly shorter than the average height of the normal population by 2 standard deviations (−2SD) or lower than the third percentile (−1.88sd) among individuals of the same race, gender, and age under normal living standards, and the bone maturity is evaluated according to bone age and less than 2 years behind the actual age [1, 2]. The rate of growth retardation in children in my country is as high as 9.9%, but the overall treatment rate is less than 1%. E main responsibility is the deficiency of the spleen and kidney, and it is related to the liver. E kidney is the congenital foundation, which controls the growth of bone marrow; the spleen is the foundation of acquired nature, which controls the metaplasia of qi and blood. E growth and development of the human body depend on the nourishment of the kidney essence and the transport and transformation functions of the spleen. Deficiency of kidney essence and lack of the source of bone marrow metaplasia will slow the growth of bones, leading to short stature, insufficient spleen source and viscera lose nourishment, resulting in growth retardation. If the liver blood is sufficient, the muscles and bones will be nourished, and if the liver blood is deficient, the muscles and bones will be dystrophic, leading to slow growth and short stature
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