A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare.

Xinzhu Zhang,Bin Deng,Youlai Yu,Kun Zhao,Feng Yuan

doi:10.1155/2021/1033900

Abstract

With an increasing elderly population worldwide, the incidence of spine degenerative diseases with neck and shoulder pain as the main symptom is rising obviously, which has now become one of the important and difficult problems in sociomedical science. This study was to explore the effects of different ratios of recombinant human bone morphogenetic protein-2 (rhBMP-2) compound to the autogenous bone on cervical interbody fusion. 90 cervical degeneration patients with the need of surgical treatment admitted to our hospital from January 2019 to January 2020 were selected as the research objects and equally divided into group A, group B, and group C according to the order of admission, with 30 cases in each group and the ratios of rhBMP-2 compound to autogenous bone being 2 : 1, 1 : 1, and 1 : 2 respectively, and standard anterior cervical diskectomy and fusion (ACDF) treatment was performed to all patients to compare their surgery-related indexes, the Japanese Orthopaedic Association (JOA) score, the visual analog scale (VAS) score, the effect of cervical interbody fusion, and the postoperative complication rate (CR). Compared with group A and group C, group B achieved the significantly better surgery-related indexes (P < 0.05), significantly higher postoperative JOA scores (P < 0.05), significantly lower postoperative neck and upper limb VAS scores (P < 0.05), significantly better effect of cervical interbody fusion (P < 0.05), and significantly lower postoperative CR (P < 0.05). 1 : 1 is the best ratio of rhBMP-2 compound to the autogenous bone, for it can optimize patients' perioperative indexes, reduce the postoperative pain, lower the possibility of complications, and improve the effect of cervical interbody fusion, which should be promoted and applied in practice.

Highlights

With an increasing elderly population worldwide, the incidence of spine degenerative diseases with neck and shoulder pain as the main symptom is rising obviously, which has become one of the important and difficult problems in sociomedical science [1,2,3]. e anterior cervical diskectomy and fusion (ACDF) is an important procedure for treating cervical diseases
The fusion materials commonly used in practice are mainly the autogenous or alloplastic bone, in which the autogenous bone is limited in extraction and the alloplastic bone may elevate the possibility of ACDF failure, so both of them do not have good application conditions
General Information. 90 cervical degeneration patients with the need of surgical treatment admitted to our hospital from January 2019 to January 2020 were selected as the research objects and divided into group A, group B, and group C according to the order of admission, with 30 cases in each group, the ratios of the recombinant human bone morphogenetic protein-2 (rhBMP-2) compound to the autogenous bone being 2 : 1, 1 : 1, and 1 : 2 respectively, and no statistical difference between the patients’ general information (P > 0.05), as given in Table 1. is study was approved by the hospital ethics committee

Summary

Introduction

With an increasing elderly population worldwide, the incidence of spine degenerative diseases with neck and shoulder pain as the main symptom is rising obviously, which has become one of the important and difficult problems in sociomedical science [1,2,3]. e anterior cervical diskectomy and fusion (ACDF) is an important procedure for treating cervical diseases. E anterior cervical diskectomy and fusion (ACDF) is an important procedure for treating cervical diseases. Patients can achieve relatively desirable outcomes after ACDF, but several studies in recent years have reported that many factors affect the prognosis of such patients, and if the surgical segments cannot achieve effective fusion, problems such as loosening of internal fixation will occur and seriously affect the postoperative recovery. Erefore, selecting the appropriate fusion material is the key to improving the rate of cervical interbody fusion for ACDF [4,5,6]. Scholars have found that the recombinant human bone morphogenetic protein-2 (rhBMP-2) can accelerate the generation rate of cells, enhance the defect repairability of bone, and fully optimize the effect of cervical interbody fusion [7,8,9,10]

Methods

Results

Discussion

Conclusion