“A CLINICAL STUDY ON PSEUDOCHOLINESTERASE LEVELS AS A PROGNOSTIC MARKER IN ORGANOPHOSPHORUS COMPOUND POISONING IN A TERTIARY CARE HOSPITAL."

Abstract

Background: One of the most common poisonings in India is organophosphorus compound poisoning. The rise in agricultural pesticide use has paralleled the rise in the use of these products for intentional self-harm. In addition to a clinical diagnosis, this requires a set biochemical parameter. The research aims to provide a useful prognostic marker in treating organophosphorus compound poisoning. Aim: Ÿ To study the pseudocholinesterase levels as a prognostic marker in the outcome of organophosphorus compound poisoning Ÿ To predict the prognosis and mortality based on pseudocholinesterase activity Materials And Methods: A Hospital-based observational Prospective study was conducted in the Department of Medicine, Santhiram medical college, and the general hospital for six months. Atotal 50 number of patients with a history of consumption of organophosphorus compounds were admitted, investigated and followed up. Results: In the study, it was noted that 70% were suicidal, and 30% were of accidental poisoning. Organophosphate compound poisoning is more common in males. The male and female ratio was 2.57:1. The maximum number of cases in our study, about 86% of cases were below 40 years. 100% of cases in the present study showed low pseudocholinesterase activity on admission. Conclusion: Determining pseudocholinesterase activity is a reliable diagnostic test in the early stages of organophosphorus poisoning. The study also demonstrates that a higher rise in enzyme activity is directly proportional to a better prognosis.