Abstract
Background : Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disorder which presents with multiple mucocutaneous manifestations along with various internal organ involvement. Skin manifestation may be either specic or nonspecic. At times, they could be an indicator of internal disease activity. To estimate the prevalence and pattern of the nonspecic mucocutaneous manifestations in Aims and objective : systemic lupus erythematosus and association with internal organ involvement. Materials and methods : This is a cross sectional study and hospital based, done at Government Rajaji Hospital, Madurai Medical College, Madurai over a period of 6 months from July 2020 to December 2020. Newly diagnosed patients are selected according to 2012 SLICC criteria and all relevant investigations were carried out. Results : A total of 23 patients were studied and the female to male ratio was 9:1. The mean of onset of the disease is 32 years and belonged to the age group of 4th decade of life. Almost all the patients had specic skin lesions and nonspecic skin lesions were observed in 80% of them (n=18). The common non specic manifestation was palmar erythema (n=7) followed by telogen efuvium in 4 patients. Small vessel vasculitis was observed in 3 patients. Livedo reticularis, sclerodactyly and urticaria were seen in 2 patients each. Features of erythromelalgia, raynauds phenomenon, PAN like vasculitis, alopecia areata, erythema nodosum & rheumatoid nodule were seen in 1 patient each. Musculoskeletal involvement is seen in majority of the patients (n=15). A strong association with signicant p value was seen between palmar erythema and renal involvement. A thorough knowledge of the various cutaneous manifestations, both Conclusion: specic and nonspecic is necessary for the early diagnosis of the disease, which in turn will help in controlling & preventing the progression of the disease. In addition some of the nonspecic cutaneous lesions can be the clinical marker of systemic association. Further studies with large sample size are needed to conrm it which are the limitations in our study.
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