Abstract
目的 探讨卡培他滨对肝细胞癌(HCC)肺转移的抑制作用.方法用免疫组织化学法检测10例HCC及其肺转移灶组织中血小板衍化内皮细胞生长因子(PD-ECGF)的表达;3例肝癌切除术后复查发现肝癌肺转移的病人采用PD-ECGF相关的卡培他滨化疗(剂量为1250 mg/m2,2次/d,口服持续14 d,再停止7 d,21 d为一个化疗周期);每例病人5～6个周期.结果 10例HCC组织中有7例表达PD-ECGF,癌周正常肝组织中表达率仅30%(3/10),而其肺转移灶组织中有8例表达.3例病人均能耐受卡培他滨治疗,未见严重的化疗并发症.1例口服卡培他滨疗程结束后复查发现肿瘤完全缓解,肺转移灶消失;1例肺转移灶稳定无进展;1例肺转移灶进展并转移至脑部.3例病人发现肝癌肺转移后生存分别已达18、13和5个月.结论 PD-ECGF在HCC肺转移灶组织中高表达,卡培他滨口服化疗可作为治疗肝癌肺转移的有效治疗措施之一。
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